Paternal age ≥40 years: An important risk factor for infertility

[Paternal age as a risk factor for congenital malformations].

BACKGROUND The role of advanced maternal age as a risk factor for congenital malformations in offspring is known. However, the influence of paternal age is not clear. AIM To evaluate the association between advanced paternal age and the risk for congenital malformations. PATIENTS AND METHODS Analysis of maternal and paternal age of cases (malformed newborns) and controls from ECLAMC Databas...

Paternal age and adverse birth outcomes: teenager or 40+, who is at risk?

BACKGROUND Most previous studies on the effect of paternal age have focused on the association of advanced paternal age with congenital anomalies. The objective of this study was to determine whether paternal age is associated with the risk of adverse birth outcomes, independent of maternal confounders. METHODS We carried out a retrospective cohort study of 2 614 966 live singletons born to m...

Age is an Important Risk Factor for Type 2 Diabetes Mellitus and Cardiovascular Diseases

Advancing Paternal Age and Risk of Autism

Advanced paternal age is a risk factor for schizophrenia in Iranians

BACKGROUND Since 1958 many, but not all studies have demonstrated that paternal age is a risk factor for schizophrenia. There may be many different explanations for differences between studies, including study design, sample size, collection criteria, heterogeneity and the confounding effects of environmental factors that can for example perturb epigenetic programming and lead to an increase in...